Translational control gone awry: a new mechanism of tumorigenesis and novel targets of cancer treatments
- 4 October 2010
- journal article
- review article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 31 (1), 1-15
- https://doi.org/10.1042/bsr20100077
Abstract
Translational control is one of primary regulation mechanisms of gene expression. Eukaryotic translational control mainly occurs at the initiation step, the speed-limiting step, which involves more than ten translation initiation factors [eIFs (eukaryotic initiation factors)]. Changing the level or function of these eIFs results in abnormal translation of specific mRNAs and consequently abnormal growth of cells that leads to human diseases, including cancer. Accumulating evidence from recent studies showed that the expression of many eIFs was associated with malignant transformation, cancer prognosis, as well as gene expression regulation. In the present paper, we perform a critical review of recent advances in understanding the role and mechanism of eIF action in translational control and cancer as well as the possibility of targeting eIFs for therapeutic development.Keywords
This publication has 97 references indexed in Scilit:
- Variation in genes required for normal mitosis and risk of breast cancerBreast Cancer Research and Treatment, 2009
- Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activityBritish Journal of Cancer, 2009
- Ribavirin targets eIF4E dependent Akt survival signalingBiochemical and Biophysical Research Communications, 2008
- An Oncogenic Role for the Phosphorylated h-Subunit of Human Translation Initiation Factor eIF3Journal of Biological Chemistry, 2008
- Loss of the eukaryotic initiation factor 3f in melanomaMolecular Carcinogenesis, 2008
- A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3Nature Genetics, 2008
- Loss of the eukaryotic initiation factor 3f in pancreatic cancerMolecular Carcinogenesis, 2007
- Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cellsProceedings of the National Academy of Sciences, 2004
- PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomasHepatology, 2003
- DNA amplification on chromosome 3q26.1-q26.3 in squamous cell carcinoma of the lung detected by reverse chromosome paintingEuropean Journal Of Cancer, 1996