Review article: coagulation disorders in chronic liver disease
Open Access
- 23 October 2007
- journal article
- review article
- Published by Wiley in Alimentary Pharmacology & Therapeutics
- Vol. 26 (s1), 21-28
- https://doi.org/10.1111/j.1365-2036.2007.03509.x
Abstract
Background The liver is the site for synthesis of the vast majority of proteins that play a central role in maintaining hemostasis, by participating in the regulation of coagulation and fibrinolysis. Aim To summarize the available data on the impact of coagulation disorders in patients with chronic liver disease. Results Hepatocellular damage in patients with severe liver disease can lead to abnormalities in the production and function of coagulation and fibrinolytic factors, disrupting the balance between coagulation and anticoagulation systems. Conclusions Hemostatic abnormalities (eg. impaired synthesis of clotting factors, heightened fibrinolysis, disseminated intravascular coagulation, thrombocytopenia, and platelet dysfunction) can increase the risk of bleeding in cirrhotic patients.Keywords
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