Metalloenzymes and Myocardial Infarction

Abstract

ALTHOUGH 90 per cent or more of the copper content of normal human blood serum can be accounted for by the metalloenzyme, ceruloplasmin, few studies concerning the variability of this protein with changes in serum copper concentration are available. Variation of serum oxidase activity in proportion to the copper content has been shown in leukemia and polyarthritis and in the neonatal period.¹ Enzymatic and immunologic technics indicate the existence of a linear relation between the serum copper and ceruloplasmin and oxidase activity in pregnancy, infection and the nephrotic syndrome.² In Wilson's disease, a disproportionate decrease of serum copper concentration and . . .