Noncanonical Inflammasomes: Caspase-11 Activation and Effector Mechanisms
Open Access
- 28 February 2013
- journal article
- Published by Public Library of Science (PLoS) in PLoS Pathogens
- Vol. 9 (2), e1003144
- https://doi.org/10.1371/journal.ppat.1003144
Abstract
Inflammasomes are cytosolic, multiprotein complexes assembled by members of the NOD-like receptor (NLR) and PYHIN protein families in response to pathogen-associated molecular patterns (PAMPs) and danger signals, and serve as activation platforms for caspase-1. Recently, a new noncanonical inflammasome pathway has been described that activates caspase-11, an understudied pro-inflammatory caspase. Despite new insights into the signaling events that control caspase-11 activation, a number of unanswered questions remain..Keywords
This publication has 16 references indexed in Scilit:
- Rapid induction of inflammatory lipid mediators by the inflammasome in vivoNature, 2012
- Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1Nature, 2012
- TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative BacteriaCell, 2012
- Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin PolymerizationImmunity, 2012
- Non-canonical inflammasome activation targets caspase-11Nature, 2011
- Detection of prokaryotic mRNA signifies microbial viability and promotes immunityNature, 2011
- Emerging inflammasome effector mechanismsNature Reviews Immunology, 2011
- Active Caspase-1 Is a Regulator of Unconventional Protein SecretionCell, 2008
- Caspase-11 Gene Expression in Response to Lipopolysaccharide and Interferon-γ Requires Nuclear Factor-κB and Signal Transducer and Activator of Transcription (STAT) 1Published by Elsevier BV ,2002
- Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICECell, 1998