Power of the two one-sided tests procedure in bioequivalence
- 1 April 1990
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Pharmacokinetics and Biopharmaceutics
- Vol. 18 (2), 137-144
- https://doi.org/10.1007/bf01063556
Abstract
The power of the two one-sided tests procedure for testing bioequivalence is derived from the bivariate noncentral tdistribution. Power curves are shown and their use in planning bioequivalence experiments discussed. Sample sizes computed in the usual manner from an analysis of variance are shown to be too small to assure a declaration of bioequivalence except under favorable conditions.Keywords
This publication has 3 references indexed in Scilit:
- A comparison of the Two One-Sided Tests Procedure and the Power Approach for assessing the equivalence of average bioavailabilityJournal of Pharmacokinetics and Biopharmaceutics, 1987
- A new statistical procedure for testing equivalence in two-group comparative bioavailability trialsJournal of Pharmacokinetics and Biopharmaceutics, 1984
- A special case of a bivariate non-central t-distributionBiometrika, 1965