Cytokine gene polymorphisms and acute liver graft rejection: A meta-analysis
- 22 December 2004
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Liver Transplantation
- Vol. 11 (1), 19-26
- https://doi.org/10.1002/lt.20316
Abstract
In the field of liver transplantation, 7 reports have been published investigating the association between polymorphisms in cytokine genes and the occurrence of acute rejection in liver graft recipients. However, most of the individual studies lack the statistical power to detect a small‐to‐moderate effect of cytokine gene polymorphisms on the acute rejection rate. To overcome this problem, we performed a quantitative meta‐analysis of 7 gene‐association studies that were comparable with regard to definition of acute rejection and the type of immunosuppression used. In the overall analysis, the interleukin (IL)‐10 polymorphism at position −1082 was identified as a genetic risk factor for acute liver graft rejection; liver transplant recipients carrying the IL‐10 −1082.A allele displayed a lower rejection rate (common odds ratio [OR], .6; 95% confidence interval [CI], .4‐.9). For the tumor necrosis factor (TNF)‐A −308 polymorphism, a common OR could not be calculated due to significant heterogeneity of ORs between the studies (mean OR, 1.4; 95% CI, .8‐2.6). No associations were found between acute liver graft rejection and single nucleotide polymorphisms in the IL‐6 (position −174) and transforming growth factor (TGF)‐β1 (positions +869 and +915) genes. In conclusion, results from this meta‐analysis suggest a role for the IL‐10 −1082 polymorphism in human liver graft rejection. (Liver Transpl 2005;11:19–26.)Keywords
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