Resequencing and mutational analysis using oligonucleotide microarrays
- 1 January 1999
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 21 (S1), 42-47
- https://doi.org/10.1038/4469
Abstract
Oligonucleotide microarray (DNA chip)-based hybridization analysis is a promising new technology which potentially allows rapid and cost-effective screens for all possible mutations and sequence variations in genomic DNA. Here, I review current strategies and uses for DNA chip-based resequencing and mutational analysis, the underlying principles of experimental designs, and future efforts to improve the sensitivity and specificity of chip-based assays.Keywords
This publication has 53 references indexed in Scilit:
- Expression profiling using cDNA microarraysNature Genetics, 1999
- Population genetics—making sense out of sequenceNature Genetics, 1999
- DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase geneNature Genetics, 1998
- DNA chips: State-of-the artNature Biotechnology, 1998
- Variations on a Theme: Cataloging Human DNA Sequence VariationScience, 1997
- Genes, Experience, and Chance in Schizophrenia--Positioning for the 21st CenturySchizophrenia Bulletin, 1997
- Expression monitoring by hybridization to high-density oligonucleotide arraysNature Biotechnology, 1996
- DNA chips: analysing sequence by hybridization to oligonucleotides on a large scaleTrends in Genetics, 1996
- Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA MicroarrayScience, 1995
- A novel method for nucleic acid sequence determinationJournal of Theoretical Biology, 1988