Microbial production of hyaluronic acid: current state, challenges, and perspectives
Open Access
- 16 November 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Microbial Cell Factories
- Vol. 10 (1), 99
- https://doi.org/10.1186/1475-2859-10-99
Abstract
Hyaluronic acid (HA) is a natural and linear polymer composed of repeating disaccharide units of β-1, 3-N-acetyl glucosamine and β-1, 4-glucuronic acid with a molecular weight up to 6 million Daltons. With excellent viscoelasticity, high moisture retention capacity, and high biocompatibility, HA finds a wide-range of applications in medicine, cosmetics, and nutraceuticals. Traditionally HA was extracted from rooster combs, and now it is mainly produced via streptococcal fermentation. Recently the production of HA via recombinant systems has received increasing interest due to the avoidance of potential toxins. This work summarizes the research history and current commercial market of HA, and then deeply analyzes the current state of microbial production of HA by Streptococcus zooepidemicus and recombinant systems, and finally discusses the challenges facing microbial HA production and proposes several research outlines to meet the challenges.Keywords
This publication has 46 references indexed in Scilit:
- Microbial production of hyaluronic acid from agricultural resource derivativesBioresource Technology, 2010
- Hyaluronic acid production by Streptococcus zooepidemicus in marine by-products media from mussel processing wastewaters and tuna peptone visceraMicrobial Cell Factories, 2010
- Optimization of medium components for high-molecular-weight hyaluronic acid production by Streptococcus sp. ID9102 via a statistical approachJournal of Industrial Microbiology & Biotechnology, 2009
- Hyaluronan Molecular Weight Is Controlled by UDP-N-acetylglucosamine Concentration in Streptococcus zooepidemicusOnline Journal of Public Health Informatics, 2009
- Comparative study on the influence of dissolved oxygen control approaches on the microbial hyaluronic acid production of Streptococcus zooepidemicusBioprocess and Biosystems Engineering, 2009
- Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applicationsBiotechnology Letters, 2006
- Stable production of hyaluronic acid in Streptococcus zooepidemicus chemostats operated at high dilution rateBiotechnology & Bioengineering, 2005
- Amplifying the cellular reduction potential of Streptococcus zooepidemicusJournal of Biotechnology, 2003
- Structured Model‐Based Analysis and Control of the Hyaluronic Acid Fermentation by Streptococcuszooepidemicus: Physiological Implications of Glucose and Complex‐Nitrogen‐Limited GrowthBiotechnology Progress, 1999
- Effect of pH, agitation and aeration on hyaluronic acid production byStreptococcus zooepidemicusBiotechnology Letters, 1994