Increased plasma HDL cholesterol levels and biliary cholesterol excretion in hamster by LCAT overexpression
- 19 June 2004
- journal article
- Published by Wiley in FEBS Letters
- Vol. 570 (1-3), 25-29
- https://doi.org/10.1016/j.febslet.2004.06.017
Abstract
Lecithin cholesterol acyltransferase (LCAT) is a key enzyme in the metabolism of high density lipoprotein (HDL), which has been found inversely correlated with atherosclerosis. Adenovirus mediated overexpression of human LCAT (hLCAT) in hamsters resulted in increased levels of plasma total cholesterol, HDL cholesterol, phospholipids and enlarged particle size of HDL. It also increased cholesterol and total bile acid concentrations in bile. Hepatic mRNA level of cholesterol 7α-hydroxylase increased 2.7-fold in hamsters. However, such effects were not observed in mice in a parallel experiment. This study suggests that overexpression of hLCAT in hamsters facilitated reverse cholesterol transport. Similar metabolic changes in humans might modify atherogenic riskThis publication has 20 references indexed in Scilit:
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