Regulation of Vitamin C Homeostasis during Deficiency
Open Access
- 24 July 2013
- Vol. 5 (8), 2860-2879
- https://doi.org/10.3390/nu5082860
Abstract
Large cross-sectional population studies confirm that vitamin C deficiency is common in humans, affecting 5%–10% of adults in the industrialized world. Moreover, significant associations between poor vitamin C status and increased morbidity and mortality have consistently been observed. However, the absorption, distribution and elimination kinetics of vitamin C in vivo are highly complex, due to dose-dependent non-linearity, and the specific regulatory mechanisms are not fully understood. Particularly, little is known about how adaptive mechanisms during states of deficiency affect the overall regulation of vitamin C transport in the body. This review discusses mechanisms of vitamin C transport and potential means of regulation with special emphasis on capacity and functional properties, such as differences in the Km of vitamin C transporters in different target tissues, in some instances demonstrating a tissue-specific distribution.This publication has 142 references indexed in Scilit:
- Maternal Vitamin C Deficiency during Pregnancy Persistently Impairs Hippocampal Neurogenesis in Offspring of Guinea PigsPLOS ONE, 2012
- The SLC23 family of ascorbate transporters: ensuring that you get and keep your daily dose of vitamin CBritish Journal of Pharmacology, 2011
- Differential regulation of the ascorbic acid transporter SVCT2 during development and in response to ascorbic acid depletionBiochemical and Biophysical Research Communications, 2011
- Promoter analysis of the human ascorbic acid transporters SVCT1 and 2: mechanisms of adaptive regulation in liver epithelial cellsThe Journal of Nutritional Biochemistry, 2011
- Vitamin C: A Concentration-Function Approach Yields Pharmacology and Therapeutic DiscoveriesAdvances in Nutrition: An International Review Journal, 2011
- Low vitamin C and increased oxidative stress and cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2Free Radical Biology & Medicine, 2010
- Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in miceJCI Insight, 2010
- Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2Free Radical Biology & Medicine, 2009
- Development of ascorbate transporters in brain cortical capillary endothelial cells in cultureBrain Research, 2008
- The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and AscorbateArchives of Biochemistry and Biophysics, 1993