A Comparison of Chitosan and Collagen Sponges as Hemostatic Dressings
- 1 January 2006
- journal article
- Published by SAGE Publications in Journal of Bioactive and Compatible Polymers
- Vol. 21 (1), 39-54
- https://doi.org/10.1177/0883911506060201
Abstract
The hemostatic capability, adhesion ability and biocompatibility of chitosan sponges were compared with commercial collagen sponges. The chitosan sponges were briefly immersed in an aqueous 20% ammonia solution before being applied to a rabbit cervical vein wound. The total amount of bleeding from the injured veins until hemostasis was similar for both chitosan and collagen sponges. The complete hemostasis success rates for both the chitosan and collagen sponges were also similar. Under hemostasis, the chitosan sponges strongly adhered to the surface of the rabbit muscles, whereas the collagen sponges were easily detached from the muscles. Under wet conditions, however, there was no significant difference in the adhesive ability between the two sponges. During implantation, the chitosan sponges were much more flexible and resistant to breakage than the collagen sponges. The biocompatibilities and biodegradation rates of the two sponges were totally different after subcutaneous implantation in rabbits. The chitosan sponge was degraded much slower than the collagen sponge, while tissue responses for the chitosan sponges were much greater than for the collagen sponges.Keywords
This publication has 20 references indexed in Scilit:
- Preparation and Characterization of Collagen/Chitosan Matrices As Potential BiomaterialsJournal of Bioactive and Compatible Polymers, 2003
- Comparison of 10 Different Hemostatic Dressings in an Aortic InjuryThe Journal of Trauma and Acute Care Surgery, 2003
- The role of fibrin sealants in hemostasisThe American Journal of Surgery, 2001
- Chitosan Hydrogel as a Base for Transdermal Delivery of Berberine and Its Evaluation in Rat Skin.Biological & Pharmaceutical Bulletin, 1999
- Chemistry and application of chitin and chitosanPolymer Degradation and Stability, 1998
- Determination of the Degree of Acetylation of Chitin/Chitosan by Pyrolysis-Gas Chromatography in the Presence of Oxalic AcidAnalytical Chemistry, 1998
- Adhesion to Soft Tissues by Gelatin-Polyanion HydrogelsThe Journal of Adhesion, 1996
- Newly Designed Hemostatic Technology Based on Photocurable GelatinASAIO Journal, 1995
- Effect of chitosan on lingual hemostasis in rabbits with platelet dysfunction induced by epoprostenolJournal of Oral and Maxillofacial Surgery, 1992
- Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissuesJournal of Controlled Release, 1985