Apolipoprotein E isoform-specific reduction of extracellular amyloid in neuronal cultures
- 10 May 1999
- journal article
- Published by Elsevier BV in Molecular Brain Research
- Vol. 68 (1-2), 181-185
- https://doi.org/10.1016/s0169-328x(99)00073-x
Abstract
Both apolipoprotein E (apoE) and amyloid peptides are associated with Alzheimer's disease (AD). Using primary hippocampal neurons, we demonstrate that apoE is capable of reducing potentially toxic extracellular amyloid peptides, likely through a receptor mediated mechanism. We hypothesize that isoform-specific differences in apoE-mediated amyloid clearance and intracellular accumulation may be responsible, at least in part, for the increased number of amyloid plaques observed in apoE ϵ4 allele AD individuals.Keywords
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