The Total Synthesis of Antrimycin Dv; II:1Synthesis of Tetrahydropyridazinecarboxylic Acid and Its Incorporation into Peptides

Abstract

Appropriately protected di- and tripeptides containing (R, S)-tetra -hydropyridazine-3-carboxylic acids were synthesized via protected γ-formyl-α-hydrazinobutyric acids. The latter compounds are obtained from acetals of either ethyl γ-formylbutyrate or ethyl γ-formyl-α-oxobutyrate.