Autoimmunity and organ damage in systemic lupus erythematosus
Top Cited Papers
- 4 May 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Immunology
- Vol. 21 (6), 605-614
- https://doi.org/10.1038/s41590-020-0677-6
Abstract
Impressive progress has been made over the last several years toward understanding how almost every aspect of the immune system contributes to the expression of systemic autoimmunity. In parallel, studies have shed light on the mechanisms that contribute to organ inflammation and damage. New approaches that address the complicated interaction between genetic variants, epigenetic processes, sex and the environment promise to enlighten the multitude of pathways that lead to what is clinically defined as systemic lupus erythematosus. It is expected that each patient owns a unique ‘interactome’, which will dictate specific treatment.Keywords
Funding Information
- U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (R37 AI 49954)
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases (RO1AI136924, R01AI085567, R01AI148161)
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