Genes, Microbes, and T Cells — New Therapeutic Targets in Crohn's Disease
- 21 February 2002
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 346 (8), 614-616
- https://doi.org/10.1056/nejm200202213460812
Abstract
NOD2, a gene conferring susceptibility to Crohn's disease, has been identified on chromosome 16. Homozygosity for a mutation that truncates the gene increases the risk of Crohn's disease by a factor of 20 to 40. No such mutations have been found in patients with ulcerative colitis. NOD2 has a role in apoptosis and in the recognition of microbial endotoxins.Keywords
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