Enhanced Metabolism of Leishmania donovani Amastigotes at Acid p H: an Adaptation for Intracellular Growth
- 13 September 1985
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 229 (4718), 1099-1101
- https://doi.org/10.1126/science.4035350
Abstract
Amastigotes (tissue forms) of Leishmania donovani isolated from infected hamster spleens carried out several physiological activities (respiration, catabolism of energy substrates, and incorporation of precursors into macromolecules) optimally at pH 4.0 to 5.5. All metabolic activities that were examined decreased sharply above the optimal pH. Promastigotes (culture forms), on the other hand, carried out the same metabolic activities optimally at or near neutral pH. This adaptation to an acid environment may account in part for the unusual ability of amastigotes to survive and multiply within the acidic environment of the phagolysosomes in vivo.This publication has 31 references indexed in Scilit:
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