The vascular endothelial growth factor family of polypeptides
- 1 November 1991
- journal article
- review article
- Published by Wiley in Journal of Cellular Biochemistry
- Vol. 47 (3), 211-218
- https://doi.org/10.1002/jcb.240470305
Abstract
Vascular endothelial growth factor (VEGF) was identified as a heparin‐binding polypeptide mitogen with a target cell specificity restricted to vascular endothelial cells. Molecular cloning reveals the existence of four species of VEGF having 121, 165, 189, and 206 amino acids. These have strikingly different secretion patterns, which suggests multiple physiological roles for this family of polypeptides. The two shorter forms are efficiently secreted, while the longer ones are mostly cell‐associated. Alternative splicing of mRNA, rather that transcription from different genes, is the mechanism for their generation. In situ hybridization reveals that the VEGF mRNA is widely distributed in most tissues and organs and expressed at particularly high levels in areas of active vascular proliferation, like the ovarian corpus luteum. Ligand autoradiography on rat tissue sections demonstrates that VEGF binding sites are associated with vascular endothelial cells of both fenestrated and non‐fenestrated capillaries and with the endothelium of large vessels, while no displaceable binding is evident on non‐endothelial cell types. These findings support the hypothesis that VEGF plays a highly specific role in the maintenance and in the induction of growth of vascular endothelial cells.Keywords
This publication has 48 references indexed in Scilit:
- Regulators of AngiogenesisAnnual Review of Physiology, 1991
- Analogous alternative splicingNature, 1990
- Vascular endothelial growth factor: A new member of the platelet-derived growth factor gene familyBiochemical and Biophysical Research Communications, 1989
- Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGFScience, 1989
- Vascular Endothelial Growth Factor Is a Secreted Angiogenic MitogenScience, 1989
- Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cellsBiochemical and Biophysical Research Communications, 1989
- Angiogenic FactorsScience, 1987
- cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell linesNature, 1986
- Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth FactorScience, 1983
- On the development of the aortae, cardinal and umbilical veins, and the other blood vessels of vertebrate embryos from capillariesThe Anatomical Record, 1909