Calibration of diffuse correlation spectroscopy with a time-resolved near-infrared technique to yield absolute cerebral blood flow measurements
Open Access
- 28 June 2011
- journal article
- Published by Optica Publishing Group in Biomedical Optics Express
- Vol. 2 (7), 2068-2081
- https://doi.org/10.1364/boe.2.002068
Abstract
A primary focus of neurointensive care is the prevention of secondary brain injury, mainly caused by ischemia. A noninvasive bedside technique for continuous monitoring of cerebral blood flow (CBF) could improve patient management by detecting ischemia before brain injury occurs. A promising technique for this purpose is diffuse correlation spectroscopy (DCS) since it can continuously monitor relative perfusion changes in deep tissue. In this study, DCS was combined with a time-resolved near-infrared technique (TR-NIR) that can directly measure CBF using indocyanine green as a flow tracer. With this combination, the TR-NIR technique can be used to convert DCS data into absolute CBF measurements. The agreement between the two techniques was assessed by concurrent measurements of CBF changes in piglets. A strong correlation between CBF changes measured by TR-NIR and changes in the scaled diffusion coefficient measured by DCS was observed (R2 = 0.93) with a slope of 1.05 ± 0.06 and an intercept of 6.4 ± 4.3% (mean ± standard error).Keywords
This publication has 51 references indexed in Scilit:
- Diffusing-wave spectroscopy with dynamic contrast variation: disentangling the effects of blood flow and extravascular tissue shearing on signals from deep tissueBiomedical Optics Express, 2010
- Effects of acetazolamide on the micro- and macro-vascular cerebral hemodynamics: a diffuse optical and transcranial doppler ultrasound studyBiomedical Optics Express, 2010
- Hemodynamic and metabolic diffuse optical monitoring in a mouse model of hindlimb ischemiaBiomedical Optics Express, 2010
- Validation of diffuse correlation spectroscopy measurements of rodent cerebral blood flow with simultaneous arterial spin labeling MRI; towards MRI-optical continuous cerebral metabolic monitoringBiomedical Optics Express, 2010
- Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defectsJournal of Biomedical Optics, 2010
- Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured AdultsNeurocritical Care, 2009
- Noninvasive optical measures of CBV, StO2, CBF index, and rCMRO2 in human premature neonates' brains in the first six weeks of lifeHuman Brain Mapping, 2009
- Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injuryJournal of Biomedical Optics, 2009
- Acute Functional Recovery of Cerebral Blood Flow after Forebrain Ischemia in RatJournal of Cerebral Blood Flow & Metabolism, 2008
- Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved systemJournal of Biomedical Optics, 2008