The Protective Effects of Taurine against Early Renal Injury in STZ-Induced Diabetic Rats, Correlated with Inhibition of Renal LOX-1-Mediated ICAM-1 Expression
Open Access
- 1 January 2008
- journal article
- research article
- Published by Taylor & Francis Ltd in Renal Failure
- Vol. 30 (8), 763-771
- https://doi.org/10.1080/08860220802272563
Abstract
Oxidative stress is a key cause in the development of diabetic nephropathy (DN). As a main receptor of oxidized low-density lipoprotein (oxLDL), LOX-1 plays an important role in the induction of leukocyte adhesion molecules, such as intercellular cell adhesion molecule-1 (ICAM-1). Taurine (TAU), a potent endogenous antioxidant, showed renoprotective effects in several model animals. This study was designed to determine the renoprotective effect and possible mechanism involved LOX-1 and ICAM-1 expression of taurine in early DN. Six-week-old male Wistar rats were divided into three groups: normal control (NC), diabetes mellitus (DM), and taurine-treated DM (DM+TAU). Diabetes was induced by streptozotocin (STZ, 60 mg/kg, i.p.). After the onset of diabetes, drinking water containing 1% taurine was given to rats in the DM+TAU group. After six weeks of treatment, blood glucose (BG), serum levels of creatinine (sCr) and BUN, and LOX-1 and ICAM-1 expression (protein and gene) in kidney cortices were estimated. Meanwhile, renal malondialdehyde (MDA) levels and glutathione peroxidase (GSH-Px) activities were examined as parameters of oxidative stress in diabetic rats. For DM+TAU rats, when compared with DM rats, the levels of serum BUN, sCr, and renal MDA were reduced, and the activities of renal GSH-Px were increased, but the BG levels were not influenced. Simultaneously, taurine attenuated histopathologic evidence of renal damages and reduced the overexpression of LOX-1 and ICAM-1 in kidney cortices of diabetic rats. In conclusion, taurine showed protective effects against early renal injury in diabetic rats. These renoprotective effects may be partly caused by suppression of oxLDL/LOX-1 system and subsequently ICAM-1 overexpression on renal cortex via its antioxidative property.Keywords
This publication has 37 references indexed in Scilit:
- The effect of taurine on renal ischemia/reperfusion injuryAmino Acids, 2006
- Taurine reverses neurological and neurovascular deficits in Zucker diabetic fatty ratsNeurobiology of Disease, 2006
- Eplerenone Shows Renoprotective Effect by Reducing LOX-1–Mediated Adhesion Molecule, PKCε-MAPK-p90RSK, and Rho-Kinase PathwayHypertension, 2005
- Taurine May Prevent Diabetic Rats from Developing Cardiomyopathy also by Downregulating Angiotensin II Type2 Receptor ExpressionCardiovascular Drugs and Therapy, 2005
- Association of Postprandial Hyperglycemia with in Vitro LDL Oxidation in Non-Smoking Patients with Type 1 Diabetes – a Cross-Sectional StudyThe Review of Diabetic Studies, 2005
- Induction of LOX‐1 and iNOS expressions by ischemia‐reperfusion of rat kidney and the opposing effect of L‐arginineThe FASEB Journal, 2003
- Statins Modulate Oxidized Low-Density Lipoprotein-Mediated Adhesion Molecule Expression in Human Coronary Artery Endothelial Cells: Role of LOX-1The Journal of pharmacology and experimental therapeutics, 2002
- Diabetes Enhances Lectin-like Oxidized LDL Receptor-1 (LOX-1) Expression in the Vascular Endothelium: Possible Role of LOX-1 Ligand and AGEBiochemical and Biophysical Research Communications, 2001
- Effect of Intravenous Taurine on Endotoxin-Induced Acute Lung Injury in SheepThe European Journal of Surgery, 2001
- Transcription factor-κB (NF-κB) and renal diseaseKidney International, 2001