Lovastatin biosynthesis in Aspergillus terreus: Characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene
- 1 July 1999
- journal article
- Published by Elsevier BV in Cell Chemical Biology
- Vol. 6 (7), 429-439
- https://doi.org/10.1016/s1074-5521(99)80061-1
Abstract
No abstract availableKeywords
This publication has 25 references indexed in Scilit:
- Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin BiosynthesisScience, 1999
- Cloning of the polyketide synthase gene atX from Aspergillus terreus and its identification as the 6-Methylsalicylic acid synthase gene by heterologous expressionMolecular Genetics and Genomics, 1996
- Demonstration of the catalytic roles and evidence for the physical association of type I fatty acid synthases and a polyketide synthase in the biosynthesis of aflatoxin B1Cell Chemical Biology, 1996
- Putative Diels−Alder-Catalyzed Cyclization during the Biosynthesis of LovastatinThe Journal of Organic Chemistry, 1996
- Biosynthesis of ML-236C and the hypocholesterolemic agents compactin by Penicillium aurantiogriseum and lovastatin by Aspergillus terreus: determination of the origin of carbon, hydrogen and oxygen atoms by 13C NMR spectrometry and observation of unusual labelling of acetate-derived oxygens by 18O2Journal of the Chemical Society, Perkin Transactions 1, 1996
- Revision of the biosynthetic origin of oxygens in mevinolin (lovastatin), a hypocholesterolemic drug from Aspergillus terreus MF 4845Journal of the American Chemical Society, 1994
- 6‐Deoxyerythronolide‐B synthase 2 from Saccharopolyspora erythraeaEuropean Journal of Biochemistry, 1992
- Structural organization of the multifunctional animal fatty‐acid synthaseEuropean Journal of Biochemistry, 1991
- The multifunctional 6‐methylsalicylic acid synthase gene of Penicillium patulumEuropean Journal of Biochemistry, 1990
- Biosynthesis of the hypocholesterolemic agent mevinolin by Aspergillus terreus. Determination of the origin of carbon, hydrogen, and oxygen atoms by carbon-13 NMR and mass spectrometryJournal of the American Chemical Society, 1985