Successful treatment of cytomegalovirus‐associated hemophagocytic syndrome by intravenous immunoglobulins
Open Access
- 11 September 2007
- journal article
- case report
- Published by Wiley in American Journal of Hematology
- Vol. 83 (2), 159-162
- https://doi.org/10.1002/ajh.21008
Abstract
Virus‐associated hemophagocytic syndrome (VAHS) is a rare complication in early cytomegalovirus (CMV) infection. There is no standard therapy for VAHS and the clinical course is variable. Data on the use of intravenous immunoglobulin (IVIG) in the treatment of CMV‐associated VAHS are limited. We report a previously healthy, 32‐year‐old woman who presented with general malaise, fever, chills, and splenomegaly. Laboratory examination showed marked elevation of aminotransferase, leucopoenia, and thrombocytopenia. Acute CMV‐infection was documented by the presence of immunoglobulin M anti‐CMV and positive viremia in blood sample. Bone marrow examination revealed extensive hemophagocytosis. IVIG was administered after the diagnosis of CMV‐associated VAHS. Her symptoms and laboratory abnormalities improved dramatically after the onset of the treatment and she did not require antiviral agent. Am. J. Hematol., 2008.This publication has 10 references indexed in Scilit:
- Systemic Lupus Erythematosus Complicated by Cytomegalovirus-Induced Hemophagocytic Syndrome and Colitis.Internal Medicine, 2002
- Human Herpesvirus 6-Associated Hemophagocytic Syndrome in a Healthy AdultEmerging Infectious Diseases, 2002
- Hemophagocytic Syndromes and InfectionEmerging Infectious Diseases, 2000
- Hemophagocytic lymphohistiocytosis in infancy and childhoodThe Journal of Pediatrics, 1997
- High doses of immunoglobulin G attenuate immune aggregate-mediated complement activation by enhancing physiologic cleavage of C3b in C3bn- IgG complexesBlood, 1996
- Immunomodulation treatment for childhood virus‐associated haemophagocytic lymphohistiocytosisBritish Journal of Haematology, 1995
- High‐dose gamma‐globulin therapy in the reactive haemophagocytic syndromeBritish Journal of Haematology, 1994
- A PROSPECTIVE RANDOMIZED STUDY OF ACYCLOVIR VERSUS GANCICLOVIR PLUS HUMAN IMMUNE GLOBULIN PROPHYLAXIS OF CYTOMEGALOVIRUS INFECTION AFTER SOLID ORGAN TRANSPLANTATION1,2Transplantation, 1994
- Familial Hemophagocytic Lymphohistiocytosis: Clinical Review Based on the Findings in Seven ChildrenActa Paediatrica, 1991
- Viral‐associated hemophagocytic syndromeMedical and Pediatric Oncology, 1990