Severity of spatial learning impairment in aging: Development of a learning index for performance in the Morris water maze.
- 1 January 2015
- journal article
- Published by American Psychological Association (APA) in Behavioral Neuroscience
- Vol. 129 (4), 540-548
- https://doi.org/10.1037/bne0000080
Abstract
The Morris water maze task was originally designed to assess the rat’s ability to learn to navigate to a specific location in a relatively large spatial environment. This article describes new measures that provide information about the spatial distribution of the rat’s search during both training and probe trial performance. The basic new measure optimizes the use of computer tracking to identify the rat’s position with respect to the target location. This proximity measure was found to be highly sensitive to age-related impairment in an assessment of young and aged male Long-Evans rats. Also described is the development of a learning index that provides a continuous, graded measure of the severity of age-related impairment in the task. An index of this type should be useful in correlational analyses with other neurobiological or behavioral measures for the study of individual differences in functional/biological decline in aging.Keywords
This publication has 15 references indexed in Scilit:
- Alterations in [3H]‐kainate receptor binding in the hippocampal formation of aged long‐evans ratsHippocampus, 1993
- Preserved configural learning and spatial learning impairment in rats with hippocampal damageHippocampus, 1992
- In vitro autoradiography of hippocampal excitatory amino acid binding in aged Fischer 344 rats: Relationship to performance on the Morris water maze.Behavioral Neuroscience, 1992
- Divergence of biological and chronological aging: Evidence from rodent studiesNeurobiology of Aging, 1991
- Individual differences in aging: Behavioral and neurobiological correlatesNeurobiology of Aging, 1989
- Degenerative Changes in Forebrain Cholinergic Nuclei Correlate with Cognitive Impairments in Aged RatsEuropean Journal of Neuroscience, 1989
- Spatial cognitive maps: Differential role of parietal cortex and hippocampal formation.Behavioral Neuroscience, 1988
- Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine-sensitive mechanismJournal of Neuroscience, 1986
- Spatial learning and motor deficits in aged ratsNeurobiology of Aging, 1984
- Place navigation impaired in rats with hippocampal lesionsNature, 1982