Interactions Between Vascular Wall and Perivascular Adipose Tissue Reveal Novel Roles for Adiponectin in the Regulation of Endothelial Nitric Oxide Synthase Function in Human Vessels
Top Cited Papers
- 4 June 2013
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 127 (22), 2209-2221
- https://doi.org/10.1161/circulationaha.112.001133
Abstract
Background—Adiponectin is an adipokine with potentially important roles in human cardiovascular disease states. We studied the role of adiponectin in the cross-talk between adipose tissue and vascular redox state in patients with atherosclerosis. Methods and Results—The study included 677 patients undergoing coronary artery bypass graft surgery. Endothelial function was evaluated by flow-mediated dilation of the brachial artery in vivo and by vasomotor studies in saphenous vein segments ex vivo. Vascular superoxide (O2−) and endothelial nitric oxide synthase (eNOS) uncoupling were quantified in saphenous vein and internal mammary artery segments. Local adiponectin gene expression and ex vivo release were quantified in perivascular (saphenous vein and internal mammary artery) subcutaneous and mesothoracic adipose tissue from 248 patients. Circulating adiponectin was independently associated with nitric oxide bioavailability and O2− production/eNOS uncoupling in both arteries and veins. These findings were ...This publication has 31 references indexed in Scilit:
- Adiponectin is associated with increased mortality and heart failure in patients with stable ischemic heart disease: Data from the Heart and Soul StudyAtherosclerosis, 2012
- A Genome-Wide Association Study Reveals a Quantitative Trait Locus of Adiponectin on CDH13 That Predicts Cardiometabolic OutcomesDiabetes, 2011
- Association of the ADIPOQ rs17360539 and rs266729 polymorphisms with type 2 diabetes: A meta-analysisMolecular and Cellular Endocrinology, 2010
- Antiatherosclerotic and Anti-Insulin Resistance Effects of Adiponectin: Basic and Clinical StudiesProgress in Cardiovascular Diseases, 2009
- Adiponectin: from obesity to cardiovascular diseaseObesity Reviews, 2009
- Local Inflammation and Hypoxia Abolish the Protective Anticontractile Properties of Perivascular Fat in Obese PatientsCirculation, 2009
- Endothelial dysfunction in adiponectin deficiency and its mechanisms involvedJournal of Molecular and Cellular Cardiology, 2009
- Stimulated HSP90 binding to eNOS and activation of the PI3–Akt pathway contribute to globular adiponectin-induced NO production: Vasorelaxation in response to globular adiponectinBiochemical and Biophysical Research Communications, 2005
- Plasma Adiponectin Levels and Risk of Myocardial Infarction in MenJAMA, 2004
- Globular adiponectin upregulates nitric oxide production in vascular endothelial cellsDiabetologia, 2003