Reduction of fossil resources, increasing the production of greenhouse gas emissions and demand growth lead to greater use of distributed energy resources in power system especially in distribution networks. Integrating these resources in order to supply local loads creates a new concept called micro-grid. Optimal operation of micro-grid in the specific time period is one of the most important problems of them. In this paper, the operation problem of micro-grids is modeled considering the economical, technical and environmental issues, as well as uncertainties related to loads, wind speed and solar radiation. The resulting model is a Mixed-Integer Non-Linear Programming (MINLP). To demonstrate the effectiveness of the proposed model, Bisheh village in Iran is considered as a case study. The results showed that considering load curtailment costs, the power losses of the main grid, the penalties of pollutant gasses emissions and the elimination of energy subsides will tremendous impacts on the operation of microgrids. Article History: Received March 12, 2016; Received in revised form June 20, 2016; Accepted July 2nd 2016; Available online How to Cite This Article: Salahi, S., and Bahramara, S. (2016) Modeling Operation Problem of Micro-grids Considering Economical, Technical and Environmental issues as Mixed-Integer Non-Linear Programming. Int. Journal of Renewable Energy Development, 5(2), 139-149. http://dx.doi.org/10.14710/ijred.5.2.139-149