The intravenous anesthetic propofol inhibits hypoxia‐inducible factor 1 activity in an oxygen tension‐dependent manner
- 28 October 2004
- journal article
- Published by Wiley in FEBS Letters
- Vol. 577 (3), 434-438
- https://doi.org/10.1016/j.febslet.2004.10.042
Abstract
Hypoxia elicits a wide range of responses that occur at different organizational levels in the body. Hypoxia is not only a signal for energy conservation and metabolic change, but triggers expression of a select set of genes. The transcription factor hypoxia-inducible factor 1 (HIF-1) is now appreciated to be a master factor of the gene induction. Although knowledge on molecular mechanisms of HIF-1 activation in response to hypoxia is accumulating, the molecular mechanism of maintenance of HIF-1 activity under normoxic conditions remains to be elucidated. We demonstrate that the intravenous anesthetic propofol reversibly inhibits HIF-1 activity and the gene expression mediated by HIF-1 by blocking the synthesis of the HIF-1α subunit under 20% or 5% O2 conditions, but not under 1% O2 conditionsThis publication has 19 references indexed in Scilit:
- Neuroprotective Effects of Propofol in a Model of Ischemic Cortical Cell CulturesAnesthesiology, 2003
- Rapid Turnover of Extracellular Signal-Regulated Kinase 3 by the Ubiquitin-Proteasome Pathway Defines a Novel Paradigm of Mitogen-Activated Protein Kinase Regulation during Cellular DifferentiationMolecular and Cellular Biology, 2003
- Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer CellsJournal of Biological Chemistry, 2002
- Hypoxia-inducible factor 1, a master transcription factor of cellular hypoxic gene expressionJournal of Anesthesia, 2002
- Hypoxia-inducible Factor-1α mRNA Contains an Internal Ribosome Entry Site That Allows Efficient Translation during Normoxia and HypoxiaMolecular Biology of the Cell, 2002
- Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1Published by Elsevier BV ,2001
- Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian CellsMolecular and Cellular Biology, 2001
- Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1Published by Elsevier BV ,1996
- Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.Proceedings of the National Academy of Sciences of the United States of America, 1995
- The widely used anesthetic agent propofol can replace α‐tocopherol as an antioxidantFEBS Letters, 1995