Long-term dynamics of CA1 hippocampal place codes
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Open Access
- 10 February 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Neuroscience
- Vol. 16 (3), 264-266
- https://doi.org/10.1038/nn.3329
Abstract
The authors use Ca2+ imaging in freely behaving mice to look at the long-term dynamics of CA1 hippocampal place codes. They find that, in a familiar environment, there is substantial change in the population of place-coding cells over time, but the ensembles of these cells are sufficiently stable to preserve an accurate spatial representation across weeks. Using Ca2+ imaging in freely behaving mice that repeatedly explored a familiar environment, we tracked thousands of CA1 pyramidal cells' place fields over weeks. Place coding was dynamic, as each day the ensemble representation of this environment involved a unique subset of cells. However, cells in the ∼15–25% overlap between any two of these subsets retained the same place fields, which sufficed to preserve an accurate spatial representation across weeks.Keywords
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