Supersensitivity after intraventricular 6-hydroxydopamine: Relation to dopamine depletion
- 1 April 1980
- journal article
- Published by Springer Science and Business Media LLC in Cellular and Molecular Life Sciences
- Vol. 36 (4), 436-438
- https://doi.org/10.1007/bf01975133
Abstract
6-Hydroxydopamine increased behavioral response to L-DOPA in proportion to the decrease of dopamine (DA) and DA utake in rat striatum. The increase response to apomorphine, however, only occurred after greater than 80% DA loss. Thus, 6-hydroxydopamine may induce postsynaptic changes only following large lesions.Keywords
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