Leisure Time Spent Sitting in Relation to Total Mortality in a Prospective Cohort of US Adults
Open Access
- 22 July 2010
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Epidemiology
- Vol. 172 (4), 419-429
- https://doi.org/10.1093/aje/kwq155
Abstract
The obesity epidemic is attributed in part to reduced physical activity. Evidence supports that reducing time spent sitting, regardless of activity, may improve the metabolic consequences of obesity. Analyses were conducted in a large prospective study of US adults enrolled by the American Cancer Society to examine leisure time spent sitting and physical activity in relation to mortality. Time spent sitting and physical activity were queried by questionnaire on 53,440 men and 69,776 women who were disease free at enrollment. The authors identified 11,307 deaths in men and 7,923 deaths in women during the 14-year follow-up. After adjustment for smoking, body mass index, and other factors, time spent sitting (≥6 vs. <3 hours/day) was associated with mortality in both women (relative risk = 1.34, 95% confidence interval (CI): 1.25, 1.44) and men (relative risk = 1.17, 95% CI: 1.11, 1.24). Relative risks for sitting (≥6 hours/day) and physical activity (<24.5 metabolic equivalent (MET)-hours/week) combined were 1.94 (95% CI: 1.70, 2.20) for women and 1.48 (95% CI: 1.33, 1.65) for men, compared with those with the least time sitting and most activity. Associations were strongest for cardiovascular disease mortality. The time spent sitting was independently associated with total mortality, regardless of physical activity level. Public health messages should include both being physically active and reducing time spent sitting.Keywords
This publication has 45 references indexed in Scilit:
- The role of body weight in the relationship between physical activity and endometrial cancer: Results from a large cohort of US womenInternational Journal of Cancer, 2008
- Daily Total Physical Activity Level and Premature Death in Men and Women: Results From a Large-Scale Population-Based Cohort Study in Japan (JPHC Study)Annals of Epidemiology, 2008
- Association of physical activity with all-cause and cardiovascular mortality: a systematic review and meta-analysisEuropean Journal of Preventive Cardiology, 2008
- Sedentary Behavior, Physical Activity, and the Metabolic Syndrome among U.S. AdultsObesity Research, 2005
- Suppression of skeletal muscle lipoprotein lipase activity during physical inactivity: a molecular reason to maintain daily low‐intensity activityThe Journal of Physiology, 2003
- Walking Compared with Vigorous Exercise for the Prevention of Cardiovascular Events in WomenThe New England Journal of Medicine, 2002
- The American Cancer Society Cancer Prevention Study II Nutrition CohortCancer, 2002
- Reproducibility and Validity of a Self-Administered Physical Activity QuestionnaireInternational Journal of Epidemiology, 1994
- Food commercials during television soap operas: What is the nutrition message?Journal of Community Health, 1992
- Physical Activity, All-Cause Mortality, and Longevity of College AlumniThe New England Journal of Medicine, 1986