Controlling gene expression in response to stress
- 3 November 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Genetics
- Vol. 12 (12), 833-845
- https://doi.org/10.1038/nrg3055
Abstract
Acute stress puts cells at risk, and rapid adaptation is crucial for maximizing cell survival. Cellular adaptation mechanisms include modification of certain aspects of cell physiology, such as the induction of efficient changes in the gene expression programmes by intracellular signalling networks. Recent studies using genome-wide approaches as well as single-cell transcription measurements, in combination with classical genetics, have shown that rapid and specific activation of gene expression can be accomplished by several different strategies. This article discusses how organisms can achieve generic and specific responses to different stresses by regulating gene expression at multiple stages of mRNA biogenesis from chromatin structure to transcription, mRNA stability and translation.Keywords
This publication has 148 references indexed in Scilit:
- Paused RNA Polymerase II as a Developmental CheckpointCell, 2011
- A Comprehensive Genomic Binding Map of Gene and Chromatin Regulatory Proteins in SaccharomycesMolecular Cell, 2011
- Recruitment Timing and Dynamics of Transcription Factors at the Hsp70 Loci in Living CellsMolecular Cell, 2010
- Translational Regulation of Gene Expression during Conditions of Cell StressMolecular Cell, 2010
- Effects of Osmolytes on the SLN1-YPD1-SSK1 Phosphorelay System from Saccharomyces cerevisiaeBiochemistry, 2009
- A Systems-Level Analysis of Perfect Adaptation in Yeast OsmoregulationCell, 2009
- Rapid, Transcription-Independent Loss of Nucleosomes over a Large Chromatin Domain at Hsp70 LociCell, 2008
- Functional Interdependence at the Chromatin Level between the MKK6/p38 and IGF1/PI3K/AKT Pathways during Muscle DifferentiationMolecular Cell, 2007
- Function and regulation in MAPK signaling pathways: Lessons learned from the yeast Saccharomyces cerevisiaeBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2007
- A Chromatin Landmark and Transcription Initiation at Most Promoters in Human CellsCell, 2007