Natural Compounds as Regulators of the Cancer Cell Metabolism
Open Access
- 1 January 2013
- journal article
- review article
- Published by Hindawi Limited in International Journal of Cell Biology
- Vol. 2013, 1-16
- https://doi.org/10.1155/2013/639401
Abstract
Even though altered metabolism is an “old” physiological mechanism, only recently its targeting became a therapeutically interesting strategy and by now it is considered an emerging hallmark of cancer. Nevertheless, a very poor number of compounds are under investigation as potential modulators of cell metabolism. Candidate agents should display selectivity of action towards cancer cells without side effects. This ideal favorable profile would perfectly overlap the requisites of new anticancer therapies and chemopreventive strategies as well. Nature represents a still largely unexplored source of bioactive molecules with a therapeutic potential. Many of these compounds have already been characterized for their multiple anticancer activities. Many of them are absorbed with the diet and therefore possess a known profile in terms of tolerability and bioavailability compared to newly synthetized chemical compounds. The discovery of important cross-talks between mediators of the most therapeutically targeted aberrancies in cancer (i.e., cell proliferation, survival, and migration) and the metabolic machinery allows to predict the possibility that many anticancer activities ascribed to a number of natural compounds may be due, in part, to their ability of modulating metabolic pathways. In this review, we attempt an overview of what is currently known about the potential of natural compounds as modulators of cancer cell metabolism.Keywords
Funding Information
- MEST of Korea for Tumor Microenvironment Global Core Research Center (2012-0001184)
This publication has 136 references indexed in Scilit:
- Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein KinaseMolecular Cell, 2012
- Hypoxia-Inducible Factors in Physiology and MedicineCell, 2012
- Nuclear PKM2 regulates β-catenin transactivation upon EGFR activationNature, 2011
- Hallmarks of Cancer: The Next GenerationCell, 2011
- The diverse functions of GAPDH: Views from different subcellular compartmentsCellular Signalling, 2011
- Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cellsGenes & Nutrition, 2010
- Identification of small molecule inhibitors of pyruvate kinase M2Biochemical Pharmacology, 2010
- Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer PathogenesisCell, 2010
- Brick by brick: metabolism and tumor cell growthCurrent Opinion in Genetics & Development, 2008
- The emerging role of lysophosphatidic acid in cancerNature Reviews Cancer, 2003