Vaccinology in the genome era
Open Access
- 1 September 2009
- journal article
- review article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 119 (9), 2515-2525
- https://doi.org/10.1172/jci38330
Abstract
Vaccination has played a significant role in controlling and eliminating life-threatening infectious diseases throughout the world, and yet currently licensed vaccines represent only the tip of the iceberg in terms of controlling human pathogens. However, as we discuss in this Review, the arrival of the genome era has revolutionized vaccine development and catalyzed a shift from conventional culture-based approaches to genome-based vaccinology. The availability of complete bacterial genomes has led to the development and application of high-throughput analyses that enable rapid targeted identification of novel vaccine antigens. Furthermore, structural vaccinology is emerging as a powerful tool for the rational design or modification of vaccine antigens to improve their immunogenicity and safety.Keywords
This publication has 117 references indexed in Scilit:
- Solution Structure of the Factor H-binding Protein, a Survival Factor and Protective Antigen of Neisseria meningitidisJournal of Biological Chemistry, 2009
- Profiling humoral immune responses to P. falciparum infection with protein microarraysProteomics, 2008
- Applications of next-generation sequencing technologies in functional genomicsGenomics, 2008
- Production and sequence validation of a complete full length ORF collection for the pathogenic bacterium Vibrio choleraeProceedings of the National Academy of Sciences of the United States of America, 2008
- Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodiesThe Journal of Experimental Medicine, 2007
- An in vivo expression technology screen for Vibrio cholerae genes expressed in human volunteersProceedings of the National Academy of Sciences of the United States of America, 2007
- The Genomes On Line Database (GOLD) in 2007: status of genomic and metagenomic projects and their associated metadataNucleic Acids Research, 2007
- Structural definition of a conserved neutralization epitope on HIV-1 gp120Nature, 2007
- A universal vaccine for serogroup B meningococcusProceedings of the National Academy of Sciences, 2006
- Identification of in vivo expressed vaccine candidate antigens from Staphylococcus aureusProceedings of the National Academy of Sciences, 2002