Morphological Features of Organelles during Apoptosis: An Overview
Open Access
- 7 May 2013
- Vol. 2 (2), 294-305
- https://doi.org/10.3390/cells2020294
Abstract
An apoptotic program leading to controlled cell dismantling implies perturbations of nuclear dynamics, as well as changes affecting the organelle structure and distribution. In human cancer cells driven to apoptosis by different stimuli, we have recently investigated the morphological properties of several organelles, including mitochondria, lysosomes, endoplasmic reticulum and Golgi apparatus. In this review, we will discuss the body of evidence in the literature suggesting that organelles are generally relocated and/or degraded during apoptosis, irrespectively of the apoptogenic stimulus and cell type.This publication has 44 references indexed in Scilit:
- Characterization of stress response in human retinal epithelial cellsJournal of Cellular and Molecular Medicine, 2012
- The ER–mitochondria interface: The social network of cell deathBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012
- Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular OrganellesInternational Journal of Cell Biology, 2012
- Apoptotic microtubule network organization and maintenance depend on high cellular ATP levels and energized mitochondriaApoptosis, 2011
- Apoptotic volume decrease as a geometric determinant for cell dismantling into apoptotic bodiesCell Death & Differentiation, 2010
- Regulation of apoptosis-associated lysosomal membrane permeabilizationApoptosis, 2010
- Lysosomal involvement in cell death and cancerBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
- Lysosomes in iron metabolism, ageing and apoptosisHistochemistry and Cell Biology, 2008
- Rearrangement of nuclear ribonucleoprotein (RNP)‐containing structures during apoptosis and transcriptional arrestBiology of the Cell, 2004
- Golgi disassembly in apoptosis: cause or effect?Trends in Cell Biology, 2003