Sensing, Signaling and Sorting Events in Kidney Epithelial Cell Physiology
Open Access
- 5 February 2009
- Vol. 10 (3), 275-284
- https://doi.org/10.1111/j.1600-0854.2008.00867.x
Abstract
The kidney regulates body fluid, ion and acid/base homeostasis through the interaction of a host of channels, transporters and pumps within specific tubule segments, specific cell types and specific plasma membrane domains. Furthermore, renal epithelial cells have adapted to function in an often unique and challenging environment that includes high medullary osmolality, acidic pHs, variable blood flow and constantly changing apical and basolateral ‘bathing’ solutions. In this review, we focus on selected protein trafficking events by which kidney epithelial cells regulate body fluid, ion and acid–base homeostasis in response to changes in physiological conditions. We discuss aquaporin 2 and G‐protein‐coupled receptors in fluid and ion balance, the vacuolar H+‐adenosine triphosphatase (V‐ATPase) and intercalated cells in acid/base regulation and acidification events in the proximal tubule degradation pathway. Finally, in view of its direct role in vesicle trafficking that we outline in this study, we propose that the V‐ATPase itself should, under some circumstances, be considered a fourth category of vesicle ‘coat’ protein (COP), alongside clathrin, caveolin and COPs.Keywords
This publication has 85 references indexed in Scilit:
- Vasopressin-stimulated Increase in Phosphorylation at Ser269 Potentiates Plasma Membrane Retention of Aquaporin-2Journal of Biological Chemistry, 2008
- Acute Hypertonicity Alters Aquaporin-2 Trafficking and Induces a MAPK-dependent Accumulation at the Plasma Membrane of Renal Epithelial CellsPublished by Elsevier BV ,2008
- Bypassing Vasopressin Receptor Signaling Pathways in Nephrogenic Diabetes InsipidusSeminars in Nephrology, 2008
- Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressinProceedings of the National Academy of Sciences, 2008
- MAL decreases the internalization of the aquaporin-2 water channelProceedings of the National Academy of Sciences of the United States of America, 2007
- Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cellsProceedings of the National Academy of Sciences, 2007
- Endosomal receptor kinetics determine the stability of intracellular growth factor signalling complexesBiochemical Journal, 2007
- PKB and megalin determine the survival or death of renal proximal tubule cellsProceedings of the National Academy of Sciences of the United States of America, 2006
- Regulation of G protein-coupled receptor export traffickingBiochimica et Biophysica Acta (BBA) - Biomembranes, 2006
- Quantitative phosphoproteomics of vasopressin-sensitive renal cells: Regulation of aquaporin-2 phosphorylation at two sitesProceedings of the National Academy of Sciences of the United States of America, 2006