Natalizumab efficacy on cognitive impairment in MS
- 10 June 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Neurological Sciences
- Vol. 31 (3), 321-323
- https://doi.org/10.1007/s10072-010-0351-0
Abstract
We report follow-up data on the efficacy of natalizumab therapy on neuropsychological impairment on an italian MS group of 39 patients at 1 year and of 11 patients at 2 years. Results show a significant reduction in relapse rate, in the number of impaired neuropsychological tests as well as in several single executive function and reasoning tests scores at 1 year. Improvement persisted at 2 years, including also memory and speed processing tasks. These data support the efficacy of natalizumab therapy in all the clinical domains, including cognitive deterioration, in multiple sclerosis patients.Keywords
This publication has 11 references indexed in Scilit:
- Efficacy and specificity of intensive cognitive rehabilitation of attention and executive functions in multiple sclerosisJournal of the Neurological Sciences, 2010
- Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: a retrospective analysis of the Natalizumab Safety and Efficacy in Relapsing-Remitting Multiple Sclerosis (AFFIRM) studyThe Lancet Neurology, 2009
- Cognitive impairment in multiple sclerosisMultiple Sclerosis Journal, 2009
- Cognitive impairment in multiple sclerosisThe Lancet Neurology, 2008
- Health‐related quality of life in multiple sclerosis: effects of natalizumabAnnals of Neurology, 2007
- A Randomized, Placebo-Controlled Trial of Natalizumab for Relapsing Multiple SclerosisThe New England Journal of Medicine, 2006
- Natalizumab: α4-integrin antagonist selective adhesion molecule inhibitors for MSExpert Review of Neurotherapeutics, 2004
- [Italian standardization and classification of Neuropsychological tests. The Italian Group on the Neuropsychological Study of Aging].1987
- Paced Auditory Serial-Addition Task: A Measure of Recovery from ConcussionPerceptual and Motor Skills, 1977
- A Simple Objective Technique for Measuring Flexibility in ThinkingThe Journal of General Psychology, 1948