Mediterranean Dietary Pattern Adherence: Associations with Prediabetes, Metabolic Syndrome, and Related Microinflammation
- 1 June 2013
- journal article
- research article
- Published by Mary Ann Liebert Inc in Metabolic Syndrome and Related Disorders
- Vol. 11 (3), 210-216
- https://doi.org/10.1089/met.2012.0168
Abstract
Background: The adherence to the Mediterranean Diet (Med Diet) seems to reduce the incidence of metabolic syndrome. The present study aimed to explore whether the adherence to the overall Med Diet pattern and to specific Med Diet items is associated with the presence of metabolic syndrome, impaired fasting glucose (IFG), insulin resistance (IR), and microinflammation in subjects free of diabetes and cardiovascular diseases. Measurements: Each patient underwent clinical assessment. Adherence to the Med Diet was measured by a previously validated 14-item questionnaire. Metabolic syndrome was defined by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria; IR was defined by homeostasis model assessment of insulin resistance (HOMA-IR); inflammation was assessed through a high-sensitivity C-reactive protein (hsCRP) assay. Results: A total of 120 subjects (64.2% women, mean age 59.8±10.2 years) were enrolled at this study. Subjects with lower Med Diet pattern adherence exhibited higher occurrence of metabolic syndrome and all its components and higher HOMA-IR and hsCRP values (P for all P=0.002) and vegetables (P=0.023). By multivariable analyses, the overall Med Diet score was found to be strongly and inversely associated with the presence of metabolic syndrome [B=−0.066; 95% confidence interval (CI) −0.105 to −0.028; P=0.001], IFG (B=−0.076; 95% CI −0.114 to −0.038; pPPPConclusions: The inverse associations between adherence to Med Diet and the prevalence of metabolic syndrome and prediabetes may be due more to the effects of the entire dietary pattern rather than to individual food components. Metabolic syndrome–related microinflammation may further be linked to specific Med Diet components.Keywords
This publication has 21 references indexed in Scilit:
- Effect of the mediterranean diet with and without weight loss on markers of inflammation in men with metabolic syndromeObesity, 2013
- A 14-Item Mediterranean Diet Assessment Tool and Obesity Indexes among High-Risk Subjects: The PREDIMED TrialPLOS ONE, 2012
- Mediterranean Diet and Type 2 Diabetes Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) StudyDiabetes Care, 2011
- The Effect of Mediterranean Diet on Metabolic Syndrome and its ComponentsJournal of the American College of Cardiology, 2011
- Standards of Medical Care in Diabetes—2011Diabetes Care, 2011
- Reduction in the Incidence of Type 2 Diabetes With the Mediterranean DietDiabetes Care, 2010
- Mediterranean-style dietary pattern, reduced risk of metabolic syndrome traits, and incidence in the Framingham Offspring CohortThe American Journal of Clinical Nutrition, 2009
- Adherence to a Mediterranean-type diet and reduced prevalence of clustered cardiovascular risk factors in a cohort of 3204 high-risk patientsEuropean Journal of Preventive Cardiology, 2008
- Mediterranean diet and insulin sensitivity, lipid profile and blood pressure levels, in overweight and obese people; The Attica studyLipids in Health and Disease, 2007
- Effect of a Mediterranean-Style Diet on Endothelial Dysfunction and Markers of Vascular Inflammation in the Metabolic SyndromeJAMA, 2004