Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate
Open Access
- 11 December 2014
- journal article
- Published by Springer Science and Business Media LLC in Cancer & Metabolism
- Vol. 2 (1), 23
- https://doi.org/10.1186/2049-3002-2-23
Abstract
No abstract availableKeywords
This publication has 28 references indexed in Scilit:
- Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stressGenes & Development, 2013
- Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipidsProceedings of the National Academy of Sciences of the United States of America, 2013
- Glutamine‐driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxiaMolecular Systems Biology, 2013
- Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viabilityProceedings of the National Academy of Sciences of the United States of America, 2011
- Reductive carboxylation supports growth in tumour cells with defective mitochondriaNature, 2011
- Liquid Chromatography–High Resolution Mass Spectrometry Analysis of Fatty Acid MetabolismAnalytical Chemistry, 2011
- Metabolomic Analysis and Visualization Engine for LC−MS DataAnalytical Chemistry, 2010
- Metabolomic Analysis via Reversed-Phase Ion-Pairing Liquid Chromatography Coupled to a Stand Alone Orbitrap Mass SpectrometerAnalytical Chemistry, 2010
- Imaging a pancreatic carcinoma xenograft model with 11C-acetate: a comparison study with 18F-FDGNuclear Medicine Communications, 2009
- Brick by brick: metabolism and tumor cell growthCurrent Opinion in Genetics & Development, 2008