F2RL3 Methylation as a Biomarker of Current and Lifetime Smoking Exposures
- 1 February 2014
- journal article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 122 (2), 131-137
- https://doi.org/10.1289/ehp.1306937
Abstract
Background: Recent genome-wide DNA methylation studies have found a pronounced difference in methylation of the F2RL3 gene (also known as PAR-4) in blood DNA according to smoking exposure. Knowledge on the variation of F2RL3 methylation by various degrees of smoking exposure is still very sparse.Keywords
This publication has 47 references indexed in Scilit:
- Heterogeneity in White Blood Cells Has Potential to Confound DNA Methylation MeasurementsPLOS ONE, 2012
- DNA Demethylation DynamicsCell, 2011
- Tobacco-Smoking-Related Differential DNA Methylation: 27K Discovery and ReplicationAmerican Journal of Human Genetics, 2011
- Global methylation profiles in DNA from different blood cell typesEpigenetics, 2011
- Dose‐response analyses using restricted cubic spline functions in public health researchStatistics in Medicine, 2010
- The global burden of cancer: priorities for preventionCarcinogenesis: Integrative Cancer Research, 2009
- Biomarkers of Induced Active and Passive Smoking DamageInternational Journal of Environmental Research and Public Health, 2009
- Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneuronsProceedings of the National Academy of Sciences of the United States of America, 2008
- Projections of Global Mortality and Burden of Disease from 2002 to 2030PLoS Medicine, 2006
- Mortality from cancer in relation to smoking: 50 years observations on British doctorsBritish Journal of Cancer, 2005