Neutrophils: New insights and open questions
- 14 December 2018
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science Immunology
- Vol. 3 (30), eaat4579
- https://doi.org/10.1126/sciimmunol.aat4579
Abstract
Neutrophils are the first line of defense against bacteria and fungi and help combat parasites and viruses. They are necessary for mammalian life, and their failure to recover after myeloablation is fatal. Neutrophils are short-lived, effective killing machines. Their life span is significantly extended under infectious and inflammatory conditions. Neutrophils take their cues directly from the infectious organism, from tissue macrophages and other elements of the immune system. Here, we review how neutrophils traffic to sites of infection or tissue injury, how they trap and kill bacteria, how they shape innate and adaptive immune responses, and the pathophysiology of monogenic neutrophil disorders.Keywords
Funding Information
- National Heart, Lung, and Blood Institute (P01 HL078784)
- National Heart, Lung, and Blood Institute (R01 HL140898)
- National Heart, Lung, and Blood Institute (P01 HL136275)
- National Heart, Lung, and Blood Institute (R01 HL088256)
- National Cancer Institute (R01 CA202987)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK113592)
- CIHR foundation (Grant)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK110162)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR070837)
- Ministero dell’Istruzione, dell’Università e della Ricerca (PRIN 2015YYKPNN)
- Associazione Italiana per la Ricerca sul Cancro (AIRC, IG-20339)
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