Treatment of steroid-sensitive nephrotic syndrome: new guidelines from KDIGO
Top Cited Papers
- 3 October 2012
- journal article
- practice guideline
- Published by Springer Science and Business Media LLC in Pediatric Nephrology
- Vol. 28 (3), 415-426
- https://doi.org/10.1007/s00467-012-2310-x
Abstract
The 2012 Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline on glomerulonephritis (GN) is intended to assist the practitioner caring for patients with GN. Two chapters of this guideline focus specifically on nephrotic syndrome in children. Guideline development followed a thorough evidence review, and management recommendations and suggestions were based on the best available evidence. Critical appraisal of the quality of evidence and strength of recommendations followed the Grades of Recommendation Assessment, Development and Evaluation (GRADE) approach. Chapters 3 and 4 of the guideline focus on the management of nephrotic syndrome in children aged 1–18 years. Guideline recommendations for children who have steroid-sensitive nephrotic syndrome (SNSS), defined by their response to corticosteroid therapy with complete remission, are addressed here. Recommendations for those with steroid-resistant nephrotic syndrome (SRNS) (i.e., do not achieve complete remission) are discussed in the companion article. Limitations of the evidence, including the paucity of large-scale randomized controlled trials, are discussed. This article provides a short description of the KDIGO process, the guideline recommendations for treatment of SSNS in children and a brief review of relevant treatment trials related to each recommendation.Keywords
This publication has 57 references indexed in Scilit:
- Treatment of steroid-resistant nephrotic syndrome in children: new guidelines from KDIGOPediatric Nephrology, 2012
- Treatment of tacrolimus or cyclosporine A in children with idiopathic nephrotic syndromePediatric Nephrology, 2012
- Short-Term Effects of Rituximab in Children with Steroid- and Calcineurin-Dependent Nephrotic SyndromeClinical Journal of the American Society of Nephrology, 2011
- Daily Corticosteroids Reduce Infection-associated Relapses in Frequently Relapsing Nephrotic SyndromeClinical Journal of the American Society of Nephrology, 2011
- Fatal pulmonary fibrosis after rituximab administrationPediatric Nephrology, 2009
- Going from evidence to recommendationsBMJ, 2008
- Pulse cyclophosphamide therapy in steroid-dependent nephrotic syndromePediatric Nephrology, 2004
- New Onset Diabetes Mellitus in Patients Receiving Calcineurin Inhibitors: A Systematic Review and Meta-AnalysisAmerican Journal of Transplantation, 2004
- Effect of Cytotoxic Drugs in Frequently Relapsing Nephrotic Syndrome with and without Steroid DependenceNew England Journal of Medicine, 1982
- Long-Term Evaluation of Chlorambucil plus Prednisone in the Idiopathic Nephrotic Syndrome of ChildhoodNew England Journal of Medicine, 1980