Implantable Self-Powered Low-Level Laser Cure System for Mouse Embryonic Osteoblasts’ Proliferation and Differentiation
- 16 July 2015
- journal article
- research article
- Published by American Chemical Society (ACS) in ACS Nano
- Vol. 9 (8), 7867-7873
- https://doi.org/10.1021/acsnano.5b03567
Abstract
Bone remodeling or orthodontic treatment is usually a long-term process. It is highly desirable to speed up the process for effective medical treatment. In this work, a self-powered low-level laser cure system for osteogenesis is developed using the power generated by the triboelectric nanogenerator. It is found that the system significantly accelerated the mouse embryonic osteoblasts’ proliferation and differentiation, which is essential for bone and tooth healing. The system is further demonstrated to be driven by a living creature’s motions, such as human walking or a mouse’s breathing, suggesting its practical use as a portable or implantable clinical cure for bone remodeling or orthodontic treatment.Funding Information
- Beijing Municipal Science and Technology Commission (Z131100006013004)
- Thousands Talents Program for Pioneer Researcher and his Innovation Team
- National Natural Science Foundation of China (31200702)
- Natural Science Foundation of Beijing Municipality (4141002, 7132121)
- Beijing Nova Program (Z121103002512019)
- China Postdoctoral Science Foundation (2014M550031)
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