DNA/ANTI‐DNA complexes
Open Access
- 1 May 1981
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 24 (5), 651-657
- https://doi.org/10.1002/art.1780240504
Abstract
The hydrodynamic sizes of antibody/3H-dsDNA immune complexes are correlated with their ability to fix complement in a red blood cell-complement linked binding assay. The results with PM2 dsDNA and a sonicated preparation (with a molecular weight of approximately 5 . 105) suggest that packing considerations are also important in the complement binding reaction. The relevance of these findings with respect to the role of antibody/dsDNA immune complexes in the pathogenesis of glomerulonephritis in systemic lupus erythematosus is discussed.This publication has 24 references indexed in Scilit:
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