Neuraminidase Activity and Free Sialic Acid Levels in the Serum of Patients with Acute Poststreptococcal Glomerulonephritis

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Abstract
It has been suggested that in acute poststreptococcal glomerulonephritis, streptococcal neuraminidase may remove sialic acid from some normal plasma or tissue component, thus rendering it antigenic. We therefore investigated serum neuraminidase activity and serum and urinary free neuraminic acid levels, using the thiobarbituric acid method, in 39 patients with acute poststreptococcal nephritis.