Radical Prostatectomy in High-Grade Prostate Cancer, Salvage and Adjuvant Radiotherapy
- 22 October 2010
- journal article
- Published by S. Karger AG in Urologia Internationalis
- Vol. 86 (2), 146-151
- https://doi.org/10.1159/000320494
Abstract
Prostate cancer with a Gleason score (GS) of 8-10 is linked to a higher risk of recurrence and progression. The aim of this paper is to evaluate treatment results of our high-risk patient cohort. The cohort of 42 patients with radical prostatectomy (RP) specimen histology GS 8-10 was assessed. The patients were followed up after RP and radiotherapy (RT) was delivered in case of a biochemical relapse. Adjuvant radiotherapy (aRT) was delivered only in case of a positive surgical margin (PSM). The following parameters were evaluated: biochemical progression-free survival (BPFS), overall survival (OS) and cancer-specific survival (CSS). The second objective was to evaluate adverse effects of RP and RT. The median follow-up time was 88 months (18-168). RP led to BPFS in 16 patients (38%). Five patients with PSM underwent aRT and 20 underwent salvage radiotherapy (sRT). One patient died of myocardial infarction and 1 patient died of metastatic disease. Skeletal metastases were recorded in 2 patients. The BPFS in RP combinations with sRT or aRT was reached in 29 patients (69%). The OS and CSS in our cohort reached 95 and 98%, respectively. Management with aRT only in PSM was very effective, according to our retrospective study.Keywords
This publication has 41 references indexed in Scilit:
- A Nomogram Predicting Prostate Cancer-Specific Mortality after Radical ProstatectomyUrologia Internationalis, 2010
- Salvage intensity-modulated radiotherapy for rising PSA after radical prostatectomyRadiotherapy and Oncology, 2008
- Adjuvant and Salvage Radiotherapy After Prostatectomy for Prostate Cancer: A Literature ReviewInternational Journal of Radiation Oncology*Biology*Physics, 2008
- The Impact of the 2005 International Society of Urological Pathology Consensus Conference on Standard Gleason Grading of Prostatic Carcinoma in Needle BiopsiesJournal of Urology, 2008
- Trends in Gleason Score: Concordance Between Biopsy and Prostatectomy over 15 YearsUrology, 2008
- Cancer Statistics, 2008CA: A Cancer Journal for Clinicians, 2008
- Identification of Patients With Prostate Cancer Who Benefit From Immediate Postoperative Radiotherapy: EORTC 22911Journal of Clinical Oncology, 2007
- Estimates of the cancer incidence and mortality in Europe in 2006Annals of Oncology, 2007
- High-grade carcinoma of the prostate: a comparison of current local therapiesUrology, 2001
- Discrepancy between Gleason Scores of Biopsy and Radical Prostatectomy SpecimensEuropean Urology, 2000