Human Polyomavirus 7-Associated Pruritic Rash and Viremia in Transplant Recipients
- 17 September 2014
- journal article
- case report
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 211 (10), 1560-1565
- https://doi.org/10.1093/infdis/jiu524
Abstract
Human polyomavirus 7 (HPyV7) is one of 11 HPyVs recently discovered through genomic sequencing technologies. Two lung transplant recipients receiving immunosuppressive therapy developed pruritic, brown plaques on the trunk and extremities showing a distinctive epidermal hyperplasia with virus-laden keratinocytes containing densely packed 36–45-nm icosahedral capsids. Rolling circle amplification and gradient centrifugation testing were positive for encapsidated HPyV7 DNA in skin and peripheral blood specimens from both patients, and HPyV7 early and capsid proteins were abundantly expressed in affected tissues. We describe for the first time that HPyV7 is associated with novel pathogenicity in some immunosuppressed individuals.Keywords
This publication has 13 references indexed in Scilit:
- Different Serologic Behavior of MCPyV, TSPyV, HPyV6, HPyV7 and HPyV9 Polyomaviruses Found on the SkinPLOS ONE, 2013
- The Rapidly Expanding Family of Human Polyomaviruses: Recent Developments in Understanding Their Life Cycle and Role in Human PathologyPLoS Pathogens, 2013
- Characterization of monoclonal antibodies specific for the Merkel cell polyomavirus capsidVirology, 2010
- Discovery of a New Human Polyomavirus Associated with Trichodysplasia Spinulosa in an Immunocompromized PatientPLoS Pathogens, 2010
- Merkel Cell Polyomavirus-Infected Merkel Cell Carcinoma Cells Require Expression of Viral T AntigensJournal of Virology, 2010
- Merkel Cell Polyomavirus and Two Previously Unknown Polyomaviruses Are Chronically Shed from Human SkinCell Host & Microbe, 2010
- Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumorsInternational Journal of Cancer, 2009
- T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirusProceedings of the National Academy of Sciences, 2008
- Clonal Integration of a Polyomavirus in Human Merkel Cell CarcinomaScience, 2008
- Production of Papillomavirus‐Based Gene Transfer VectorsCurrent Protocols in Cell Biology, 2007