A Thermoresponsive Bubble-Generating Liposomal System for Triggering Localized Extracellular Drug Delivery
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- 14 December 2012
- journal article
- research article
- Published by American Chemical Society (ACS) in ACS Nano
- Vol. 7 (1), 438-446
- https://doi.org/10.1021/nn304474j
Abstract
The therapeutic effectiveness of chemotherapy is optimal only when tumor cells are subjected to a maximum drug exposure. To increase the intratumoral drug concentration and thus the efficacy of chemotherapy, a thermoresponsive bubble-generating liposomal system is proposed for triggering localized extracellular drug delivery. The key component of this liposomal formulation is the encapsulated ammonium bicarbonate (ABC), which is used to create the transmembrane gradient needed for a highly efficient encapsulation of doxorubicin (DOX). At an elevated temperature (42 °C), decomposition of ABC generates CO2 bubbles, creating permeable defects in the lipid bilayer that rapidly release DOX and instantly increase the drug concentration locally. Because the generated CO2 bubbles are hyperechogenic, they also enhance ultrasound imaging. Consequently, this new liposomal system encapsulated with ABC may also provide an ability to monitor a temperature-controlled drug delivery process.Keywords
This publication has 31 references indexed in Scilit:
- Quantitative structure - property relationship modeling of remote liposome loading of drugsJournal of Controlled Release, 2011
- Optimization of a novel and improved thermosensitive liposome formulated with DPPC and a Brij surfactant using a robust in vitro systemJournal of Controlled Release, 2011
- Influence of Nano-Carrier Architecture on in Vitro siRNA Delivery Performance and in Vivo Biodistribution: Polyplexes vs MicelleplexesACS Nano, 2011
- Stimuli-Responsive Liposome Fusion Mediated by Gold NanoparticlesACS Nano, 2010
- Nanobubbles from Gas‐Generating Polymeric Nanoparticles: Ultrasound Imaging of Living SubjectsAngewandte Chemie-International Edition, 2010
- Development and optimization of a doxorubicin loaded poly(lactic acid) contrast agent for ultrasound directed drug deliveryJournal of Controlled Release, 2010
- Masking and triggered unmasking of targeting ligands on nanocarriers to improve drug delivery to brain tumorsBiomaterials, 2009
- Tumor-Targeted Nanomedicines: Enhanced Antitumor Efficacy In vivo of Doxorubicin-Loaded, Long-Circulating Liposomes Modified with Cancer-Specific Monoclonal AntibodyClinical Cancer Research, 2009
- Multiple Lipid Compartments Slow Vesicle Contents Release in Lipases and SerumACS Nano, 2007
- Pulsed-High Intensity Focused Ultrasound and Low Temperature–Sensitive Liposomes for Enhanced Targeted Drug Delivery and Antitumor EffectClinical Cancer Research, 2007