The Effect of Propranolol on Portal Hypertension in Patients with Cirrhosis: A Hemodynamic Study
Open Access
- 1 September 1982
- journal article
- clinical trial
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Hepatology
- Vol. 2 (5), 523S-527S
- https://doi.org/10.1002/hep.1840020502
Abstract
The gradient between wedged and free hepatic venous pressures was measured in patients with alcoholic cirrhosis before and 1, 3, and 9 months after continuous oral administration of propranolol at doses reducing the heart rate by 25% or after administration of a placebo. The gradient between wedged and free hepatic venous pressures decreased throughout the duration of propranolol administration, and it did not significantly change in the patients receiving placebo. Since the gradient between wedged and free hepatic venous pressures closely reflects portal venous pressure in alcoholic cirrhosis, it is concluded that continuous oral administration of propranolol produced sustained reduction in portal venous pressure in these patients.This publication has 8 references indexed in Scilit:
- Propranolol for Prevention of Recurrent Gastrointestinal Bleeding in Patients with CirrhosisThe New England Journal of Medicine, 1981
- PROPRANOLOL—A MEDICAL TREATMENT FOR PORTAL HYPERTENSION?The Lancet, 1980
- Direct Transhepatic Measurement of Portal Vein Pressure Using a Thin NeedleGastroenterology, 1977
- Thermodilution cardiac output determination with a single flow-directed catheterAmerican Heart Journal, 1972
- The Paradox of Beta-Adrenergic Blockade in HypertensionCirculation, 1968
- Control of the Splanchnic Circulation in ManCirculation Research, 1967
- Effect of Pitressin on the Splanchnic Circulation in ManCirculation, 1961
- Circulatory changes in chronic liver diseaseThe American Journal of Medicine, 1958