Treatment of depression in diabetes: an update
- 1 March 2009
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Psychiatry
- Vol. 22 (2), 211-217
- https://doi.org/10.1097/yco.0b013e3283207b45
Abstract
The combination of depression and diabetes is common and especially harmful because depression has a strong impact on psychosocial as well as medical outcomes in patients with diabetes. Consequently, treatment for depression in diabetes is also aimed at improvement in glycemic control and risk reduction for diabetes complications and mortality. This review provides an overview of all published, randomized controlled trials on the treatment of depression in patients with diabetes and summarizes current, ongoing research. The best results for medical and psychological outcomes were observed for psychological treatments; however, the generalizability of these results is restricted by methodological limitations. Most antidepressants were effective treatments for depression in diabetes but failed to show benefits regarding diabetes-related medical variables. Algorithm-based care, including psychological and psychopharmacological approaches, provides the best scientific evidence for successful depression treatment but not for glycemic control. Depression can be treated with antidepressants, psychotherapy or a flexible combination of both with relatively good results that are comparable to those for patients who have depression but not diabetes. Up to now, no single treatment that consistently leads to better medical outcomes in patients with both depression and diabetes has been clearly identified.Keywords
This publication has 31 references indexed in Scilit:
- Examining a Bidirectional Association Between Depressive Symptoms and DiabetesJAMA, 2008
- A comparison of baseline sociodemographic and clinical characteristics between major depressive disorder patients with and without diabetes: A STAR⁎D reportJournal of Affective Disorders, 2008
- Economic Costs of Diabetes in the U.S. in 2007Diabetes Care, 2008
- Recent advances in understanding depression in adults with diabetesCurrent Diabetes Reports, 2007
- Mood disorders: cardiovascular and diabetes comorbidityCurrent Opinion in Psychiatry, 2006
- Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysisDiabetologia, 2006
- Diabetes complications and depression as predictors of health service costsGeneral Hospital Psychiatry, 2005
- Global Prevalence of DiabetesDiabetes Care, 2004
- The Prevalence of Comorbid Depression in Adults With DiabetesDiabetes Care, 2001
- Depression and poor glycemic control: a meta-analytic review of the literature.Diabetes Care, 2000