Review Article: Genetics of Alzheimer Disease
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Open Access
- 2 November 2010
- journal article
- review article
- Published by SAGE Publications in Journal of Geriatric Psychiatry and Neurology
- Vol. 23 (4), 213-227
- https://doi.org/10.1177/0891988710383571
Abstract
Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the elderly individuals. Clinically, patients initially present with short-term memory loss, subsequently followed by executive dysfunction, confusion, agitation, and behavioral disturbances. Three causative genes have been associated with autosomal dominant familial AD (APP, PSEN1, and PSEN2) and 1 genetic risk factor (APOEε4 allele). Identification of these genes has led to a number of animal models that have been useful to study the pathogenesis underlying AD. In this article, we provide an overview of the clinical and genetic features of AD.Keywords
This publication has 140 references indexed in Scilit:
- Global prevalence of dementia: a Delphi consensus studyThe Lancet, 2006
- Functional γ-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and γ-secretase substratesNeurobiology of Disease, 2003
- Reconstitution of γ-secretase activityNature, 2003
- APP Processing and Synaptic Plasticity in Presenilin-1 Conditional Knockout MiceNeuron, 2001
- Is ϵ4 the ancestral human apoE allele?Neurobiology of Aging, 1999
- Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset FamiliesScience, 1993
- Neuropathological stageing of Alzheimer-related changesActa Neuropathologica, 1991
- Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseNature, 1991
- APP-695 transcript prevalence is selectively reduced during Alzheimer's disease in cortex and hippocampus but not in cerebellumNeurobiology of Aging, 1989
- Clinical diagnosis of Alzheimer's diseaseNeurology, 1984