Role of Lymphotoxin and the Type I TNF Receptor in the Formation of Germinal Centers
- 1 March 1996
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 271 (5253), 1289-1291
- https://doi.org/10.1126/science.271.5253.1289
Abstract
In mice deficient in either lymphotoxin-α (LT-α) or the type I tumor necrosis factor (TNF) receptor, but not the type II TNF receptor, germinal centers failed to develop in peripheral lymphoid organs. Germinal center formation was restored in LT-α-deficient mice by transplantation of normal bone marrow, indicating that the LT-α-expressing cells required to establish this lymphoid structure are derived from bone marrow.Keywords
This publication has 22 references indexed in Scilit:
- Humoral immune responses in CD40 ligand-deficient mice.The Journal of Experimental Medicine, 1994
- Mice deficient for the CD40 ligandImmunity, 1994
- The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formationImmunity, 1994
- A Lymphotoxin-β-Specific ReceptorScience, 1994
- Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in LymphotoxinScience, 1994
- Molecular Pathology of X‐Linked Immunoglobulin Deficiency with Normal or Elevated IgM (HIGMX‐1)Immunological Reviews, 1994
- Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenesNature, 1993
- Two TNF receptorsImmunology Today, 1992
- Crystallization and preliminary X-ray investigation reveals that tumor necrosis factor is a compact trimer furnished with 3-fold symmetryJournal of Molecular Biology, 1988
- Peanut lectin binding properties of germinal centers of mouse lymphoid tissueNature, 1980