Direct effects of thyroid hormones on hepatic lipid metabolism
- 23 February 2018
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Endocrinology
- Vol. 14 (5), 259-269
- https://doi.org/10.1038/nrendo.2018.10
Abstract
Thyroid hormones regulate hepatic lipid metabolism in a cell autonomous manner Thyroid hormone receptors (THRα and THRβ) differentially regulate hepatic lipid metabolism Thyroid hormone induces the expression of genes that encode proteins involved in hepatic lipogenesis Thyroid hormone couples autophagy to mitochondrial fat oxidation to induce ketogenesis Thyroid hormone induces reverse cholesterol transport Thyroid hormone analogues and/or mimetics offer therapeutic alternatives for treatment of lipid-associated hepatic pathologiesKeywords
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